Rhone River, historic river of Switzerland and France and one of the most significant waterways of Europe. It is the only major river flowing directly to the Mediterranean Sea and is thoroughly Alpine in character. The scenic and often wild course of the Rhône, the characteristics of the water flowing in it, and the way it has been used by humans have all been shaped by the influences of the mountains, right down to the river mouth, where sediments marking the Rhône’s birth in an Alpine glacier are carried into the warmer waters of the Mediterranean.Rhone River cruises explore the beautiful Provence region in southern France. Often, sailings of the Rhone are paired with sailings of the Saone River, which runs through the Burgundy region.